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Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization

TitleAntimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization
Publication TypeJournal Article
Year of Publication2000
AuthorsCinel, B, Roberge, M, Behrisch, H, van Ofwegen, LP, Castro, CB, Andersen, RJ
JournalOrganic Letters
Volume2
Pagination257-260
Date PublishedFeb
Type of ArticleArticle
ISBN Number1523-7060
KeywordsAGENTS, ELEUTHEROBIN, TAXOL, TUBULIN
Abstract

[GRAPHICS] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum, Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.
URL<Go to ISI>://000085238900007