Title | An Approach to the Bis-oxazole Macrocycle of Diazonamides |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Zhang, J, Ciufolini, MA |
Journal | ORGANIC LETTERS |
Volume | 13 |
Pagination | 390-393 |
Date Published | FEB 4 |
ISSN | 1523-7060 |
Abstract | A convergent approach to a macrocyclic compound embodying the complete ``eastern{''} quadrant of diazonamides is described. The opening sequence in this work relies on an oxazole-forming reaction devised earlier in this group, while a late step involves a Robinson-Gabriel cyclization of an amidoketone to form a second oxazole. |
DOI | 10.1021/ol102678j |