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Autophagy-modulating aminosteroids isolated from the sponge Cliona celata

TitleAutophagy-modulating aminosteroids isolated from the sponge Cliona celata
Publication TypeJournal Article
Year of Publication2008
AuthorsKeyzers, RA, Daoust, J, Davies-Coleman, MT, Van Soest, R, Balgi, A, Donohue, E, Roberge, M, Andersen, RJ
JournalOrganic Letters
Volume10
Pagination2959-2962
Date PublishedJul
Type of ArticleArticle
ISBN Number1523-7060
Keywords2 STEROIDAL ALKALOIDS, CORTICIUM SP, marine sponge, YEAST
Abstract

Clionamines A-D (1-4), new aminosteroids that modulate autophagy, have been isolated from South African specimens of the sponge Cliona celata. Clionamine D (4) has an unprecedented spiro bislactone side chain.
URL<Go to ISI>://000257629200011