| Title | Bafilomycins Produced in Culture by Streptomyces spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Carr, G, Williams, DE, Diaz-Marrero, AR, Patrick, BO, Bottriell, H, Balgi, AD, Donohue, E, Roberge, M, Andersen, RJ |
| Journal | Journal of Natural Products |
| Volume | 73 |
| Pagination | 422 - 427 |
| Date Published | 2010/// |
| ISBN Number | 0163-3864 |
| Keywords | Streptomyces bafilomycin isolation autophagy inhibitor |
| Abstract | Five new bafilomycins, F (1) to J (5), have been isolated from lab. cultures of two Streptomyces spp. obtained from marine sediments collected in British Columbia, and their structures have been elucidated by detailed anal. of spectroscopic data and the synthesis of model compds. The new bafilomycins F (1), G (2), H (3), and J (5) along with several co-occurring known analogs showed potent inhibition of autophagy in microscopy and biochem. assays. The thiomorpholinone fragment present in bafilomycin F (1) has not previously been found in a natural product. [on SciFinder(R)] |
