| Title | BETA-GLUCOSIDASE INHIBITORS INCORPORATING PYRIDINIUM AS A GLUCOSYL MIMIC |
| Publication Type | Journal Article |
| Year of Publication | 1995 |
| Authors | Knapp, S, DONG, YH, RUPITZ, K, Withers, SG |
| Journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| Volume | 5 |
| Pagination | 763-766 |
| Date Published | APR 6 |
| ISSN | 0960-894X |
| Abstract | The synthesis of several 2-pyridylthio-based pseudo-disaccharides (5 - 9) is described. One of them, them, 5a, shows inhibition of Agrobacterium beta-glucosidase (K-i = 800 mu M), possibly because in protonated form it mimics the protonated substrate (or transition state, compare I) lending to the glucopyranosyl cation. |
| DOI | 10.1016/0960-894X(95)00111-6 |
