| Title | Cationic technetium and rhenium complexes with pendant carbohydrates. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Ferreira, CL, Marques, FLN, Okamoto, MRY, Otake, AH, Sugai, Y, Mikata, Y, Storr, T, Bowen, M, Yano, S, Adam, MJ, Chammas, R, Orvig, C |
| Journal | Applied Radiation and Isotopes |
| Volume | 68 |
| Pagination | 1087 - 1093 |
| Date Published | 2010/// |
| ISBN Number | 0969-8043 |
| Keywords | isotope labeling technetium rhenium glucopyranoside pyridylaminoethyl deriv carbonyl complex, technetium rhenium glucopyranoside pyridylaminoethyl deriv carbonyl complex prepn biodistribution |
| Abstract | Rhenium(I) and technetium(I) complexes with three dipicolylamine carbohydrate-conjugated chelators (L), 2-bis(2-pyridinylmethyl)aminoethyl-1-deoxy-1-thio-β-D-glucopyranoside (L1), O1-2-bis(2-pyridinylmethyl)aminoethyl-β-D-glucopyranoside (L2), and N-(2-bis(2-pyridinylmethyl)carboxamido-2-deoxy-D-glucopyranose) (L3) M(CO)3L+ (M = Tc, Re) were formed by complexing to the [M(CO)3]+ core and the properties of the resulting complexes were investigated. Synthesis and characterization of the chelator L1 and the corresponding Re complex are reported. All chelators were radiolabeled in high yield with [99mTc(CO)3(H2O)3]+ (>98%) and [186Re(CO)3(H2O)3]+ (>80%). The chelators and Re-complexes were detd. to not be substrates for the glucose metab. enzyme hexokinase. However, the biodistribution of each of the 99mTc complexes demonstrated fast clearance from most background tissue, including >75% clearance of the activity in the kidneys and the liver within 2 h post-injection. [on SciFinder(R)] |
