| Title | Cladoniamides A-G, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Williams, DE, Davies, J, Patrick, BO, Bottriell, H, Tarling, T, Roberge, M, Andersen, RJ |
| Journal | Organic Letters |
| Volume | 10 |
| Pagination | 3501-3504 |
| Date Published | Aug |
| Type of Article | Article |
| ISBN Number | 1523-7060 |
| Keywords | biosynthesis, CHROMOPYRROLIC ACID, REBECCAMYCIN |
| Abstract | Cladoniamides A-G (3-9) have been isolated from cultures of Streptomyces uncialis, and their structures have been elucidated by a combination of spectroscopic analysis and an X-ray diffraction analysis of cladoniamide A (3). The cladoniamides have unprecedented rearranged and degraded alkaloid skeletons with putative biogenetic origins from indolocarbazole precursors. Cladoniamide G (9) is cytotoxic to MCF-7 cells in vitro at 10 mu g/mL. |
| URL | <Go to ISI>://000258293100031 |
