|Title||Construction of Carbo- and Heterocycles Using Radical Relay Cyclizations Initiated by Alkoxy Radicals|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Zhu, H, Wickenden, JG, Campbell, NE, Leung, JCT, Johnson, KM, Sammis, GM|
|Type of Article||Article|
|Keywords||1, 5-HYDROGEN ATOM TRANSFER, AMPHIDINOLIDE K, C-H ACTIVATION, CARBONYLATION, CHAIN REACTIONS, EFFICIENT, FUNCTIONALIZATION, ORGANIC-SYNTHESIS, REARRANGEMENT, TRANSLOCATION REACTIONS|
An efficient method for the rapid construction of carbo- and heterocycles has been developed using radical relay cyclizations initiated by alkoxy radicals. Linear substrates were cyclized to form a wide range of cyclopentane, pyrrolidine, tetrahydropyran, and tetrahydrofuran derivatives in excellent yields. This methodology was utilized as a key step in the synthesis of the tetrahydrofuran fragment in (-)-amphidinolide K.
|URL||<Go to ISI>://000265529000039|