Research & Teaching Faculty

Default Header Image

Coordination chemistry of vanadium in metallopharmaceutical candidate compounds

TitleCoordination chemistry of vanadium in metallopharmaceutical candidate compounds
Publication TypeJournal Article
Year of Publication2001
AuthorsThompson, KH, Orvig, C
JournalCoordination Chemistry Reviews
Volume219
Pagination1033-1053
Date PublishedSep-Oct
Type of ArticleReview
ISBN Number0010-8545
Keywordsbioactivity, BIOLOGICAL-ACTIVITY, CANCER, CRYSTAL-STRUCTURE, Diabetes mellitus, DIABETES-MELLITUS, ESEEM, INSULIN-LIKE ACTIVITIES, OXIDATIVE STRESS, OXOVANADIUM(IV) COMPLEXES, OXYGEN-BRIDGED DIMER, PEROXO HETEROLIGAND VANADATES(V), pharmaceutical agents, RAY, SPECTROSCOPIC PROPERTIES, structure-activity relationships, TYROSINE PHOSPHORYLATION, vanadium complexes
Abstract

The discovery of vanadium’s insulin-like behaviour in vitro, and later of the orally available glucose- and lipid-lowering capability of these same compounds in vivo, has stimulated renewed interest in vanadium coordination chemistry. Besides the anti-diabetic effects for which it is now so well known, vanadium also exhibits a number of other therapeutic effects including anti-tumour and anti-inflammatory activities. In this review, emphasis will be on the most recent developments in the coordination chemistry of vanadium(III), (IV) and (V), as related to development of these compounds for pharmaceutical use. How best to measure bioactivity and the pharmaceutical relevance of accompanying increased oxidative stress will also be considered. (C) 2001 Elsevier Science B.V. All rights reserved.

URL<Go to ISI>://000171343600035