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CYTOTOXIC ALKALOIDS FROM THE FLATWORM PROSTHECERAEUS-VILLATUS AND ITS TUNICATE PREY CLAVELINA-LEPADIFORMIS

TitleCYTOTOXIC ALKALOIDS FROM THE FLATWORM PROSTHECERAEUS-VILLATUS AND ITS TUNICATE PREY CLAVELINA-LEPADIFORMIS
Publication TypeJournal Article
Year of Publication1995
AuthorsKubanek, J, Williams, DE, De Silva, ED, Allen, T, Andersen, RJ
JournalTetrahedron Letters
Volume36
Pagination6189-6192
Date PublishedAug
Type of ArticleArticle
ISBN Number0040-4039
Abstract

Four novel alkaloids, lepadins B (2) and C (3) and villatamines A (4) and B (5), have been isolated from the predatory flatworm Prostheceraeus villatus and its tunicate prey Clavelina lepadiformis. Lepadins A (1) and B (2) and villatamine B (5) exhibit significant in vitro cytotoxicity against human cancer cell lines.
URL<Go to ISI>://A1995RR85400002