Title | DESIGN AND SYNTHESIS OF ANALOGS OF IONOMYCIN |
Publication Type | Journal Article |
Year of Publication | 1994 |
Authors | Hu, TQ, Weiler, L |
Journal | Canadian Journal of Chemistry-Revue Canadienne De Chimie |
Volume | 72 |
Pagination | 1500-1511 |
Date Published | Jun |
Type of Article | Article |
ISBN Number | 0008-4042 |
Keywords | ACID, HOST-GUEST COMPLEXATION, IONOPHORE, RESOLUTION |
Abstract | Based on the analysis of the crystal structure of the Ca2+ salt of ionomycin and the chemical and physical data on ionomycin, a number of ionomycin analogues have been synthesized to study the structural features affecting the Ca2+ binding and transport. Compounds 2, 3, and 4 were synthesized to study the effect of additional intramolecular oxygen coordination sites on Ca2+ transport. Compounds 5a-5d were prepared to study the effect of lipid solubility on Ca2+ binding and transport. Compounds 6a-6c were prepared to study the effect of the distance between the P-diketone and the carboxyl group on Ca2+ transport. A general synthetic route to these compounds has been developed. The key reactions in this route are the consecutive regioselective alkylations of the dianion of 2,4-pentanedione with the appropriate bromides. |
URL | <Go to ISI>://A1994NV30900010 |