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Design of targeting ligands in medicinal inorganic chemistry

TitleDesign of targeting ligands in medicinal inorganic chemistry
Publication TypeJournal Article
Year of Publication2006
AuthorsStorr, T, Thompson, KH, Orvig, C
JournalChemical Society Reviews
Volume35
Pagination534-544
Type of ArticleReview
ISBN Number0306-0012
KeywordsCANCER, COMPLEXES, FLUORESCENCE, GADOLINIUM, IN-VITRO, PARACEST AGENTS, PROTEINS, RECEPTOR, therapy, TRANSPORT
Abstract

This tutorial review will highlight recent advances in medicinal inorganic chemistry pertaining to the use of multifunctional ligands for enhanced effect. Ligands that adequately bind metal ions and also include specific targeting features are gaining in popularity due to their ability to enhance the efficacy of less complicated metal-based agents. Moving beyond the traditional view of ligands modifying reactivity, stabilizing specific oxidation states, and contributing to substitution inertness, we will discuss recent work involving metal complexes with multifunctional ligands that target specific tissues, membrane receptors, or endogenous molecules, including enzymes.

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