Title | Detailed structural analysis of glycosidase/inhibitor interactions: Complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Notenboom, V, Williams, SJ, HOOS, R, Withers, SG, ROSE, DR |
Journal | BIOCHEMISTRY |
Volume | 39 |
Pagination | 11553-11563 |
Date Published | SEP 26 |
ISSN | 0006-2960 |
Abstract | {Detailed insights into the mode of binding of a series of tight-binding aza-sugar glycosidase inhibitors of two fundamentally different classes are described through X-ray crystallographic studies of complexes with the retaining family 10 xylanase Cex from Cellulomonas fimi. Complexes with xylobiosederived aza-sugar inhibitors of the substituted ``amidine{''} class (xylobio-imidazole |
DOI | 10.1021/bi0010625 |
