| Title | The effect of organotin compounds on the permeability of model biological membranes |
| Publication Type | Journal Article |
| Year of Publication | 1997 |
| Authors | Cullen, WR, Herring, FG, Nwata, BU |
| Journal | Applied Organometallic Chemistry |
| Volume | 11 |
| Pagination | 369-379 |
| Date Published | May |
| Type of Article | Proceedings Paper |
| ISBN Number | 0268-2605 |
| Keywords | bilayer, DIMETHYLARSINIC ACID, efflux, egg, ERYTHROCYTE, EXCHANGE, facilitated diffusion, LIPOSOMES, membrane modification, monobutyltin, NMR, PHOSPHATIDYLCHOLINE, tributyltin chloride, trichloride |
| Abstract | The efflux of dimethylarsinic acid (DMA) from liposomes formed from egg phosphatidylcholine (EPC) is increased when tributyltin chloride (TBT) is added to the extraliposomal compartment; however the addition of monobutyltin trichloride (MBT) slows down the efflux. When the liposomes are prepared from EPC and organotin compounds, different mechanisms for DMA efflux seem to operate: TBT-EPC liposomes show a mixture of facilitated and passive diffusion; MBT-EPC liposomes show only passive diffusion. The facilitated diffusion of DMA(-) seems to be stopped by the addition of TBT to the extraliposomal compartment. (C) 1997 by John Wiley & Sons, Ltd. |
| URL | <Go to ISI>://A1997WZ73300003 |
