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EFFICIENT COUPLING OF AMINO-ACID DERIVATIVES TO RIGID ORGANIC SCAFFOLDS - MODEL SYNTHESES FOR DE-NOVO PROTEINS

TitleEFFICIENT COUPLING OF AMINO-ACID DERIVATIVES TO RIGID ORGANIC SCAFFOLDS - MODEL SYNTHESES FOR DE-NOVO PROTEINS
Publication TypeJournal Article
Year of Publication1995
AuthorsGibb, BC, Mezo, AR, Causton, AS, Fraser, JR, Tsai, FCS, Sherman, JC
JournalTetrahedron
Volume51
Pagination8719-8732
Date PublishedAug
Type of ArticleArticle
ISBN Number0040-4020
KeywordsBUNDLE PROTEIN, DESIGN, PEPTIDE, TASP
Abstract

We describe the coupling of amino acid derivatives to four different rigid organic macrocycles. The couplings were achieved in high yields, which augurs well for the coupling of polypeptides to the rigid macrocycles to create a new family of de novo proteins. We discuss the structure of the model compounds based on the hydrogen bonding patterns that are evident from their NMR and IR spectra.

URL<Go to ISI>://A1995RM78400004