|Title||``Extreme'' Ugi Reactions With Some Complex alpha-Amino Acids|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Turner, CDylan, Ciufolini, MA|
|Date Published||SEP 21|
The Ti(IV)-catalyzed Ugi condensation of alpha-amino acids with electron-rich aromatic aldehydes performs adequately even with sterically demanding alpha-amino carboxylate salts. The reaction occurs diastereoselectively, in some cases with virtually complete diastereoselectivity. A stereochemical rationale for the reaction is proposed.