Title | ``Extreme'' Ugi Reactions With Some Complex alpha-Amino Acids |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Turner, CDylan, Ciufolini, MA |
Journal | ORGANIC LETTERS |
Volume | 14 |
Pagination | 4970-4973 |
Date Published | SEP 21 |
ISSN | 1523-7060 |
Abstract | The Ti(IV)-catalyzed Ugi condensation of alpha-amino acids with electron-rich aromatic aldehydes performs adequately even with sterically demanding alpha-amino carboxylate salts. The reaction occurs diastereoselectively, in some cases with virtually complete diastereoselectivity. A stereochemical rationale for the reaction is proposed. |
DOI | 10.1021/ol302379a |
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