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A glucosamine dipicolylamine conjugate of Tc-99m(I) and Re-186(I) for use in imaging and therapy

TitleA glucosamine dipicolylamine conjugate of Tc-99m(I) and Re-186(I) for use in imaging and therapy
Publication TypeJournal Article
Year of Publication2005
AuthorsStorr, T, Fisher, CL, Mikata, Y, Yano, S, Adam, MJ, Orvig, C
JournalDalton Transactions
Pagination654-655
Type of ArticleArticle
ISBN Number1477-9226
KeywordsACID, BIOMOLECULES, COMPLEXES, RADIOPHARMACEUTICALS, RE
Abstract

The synthesis and metal complexation of a glucosamine-appended 2,2’-dipicolylamine ligand to the tricarbonyls of Tc-99m and Re-186 is described; the ligand was found to bind in a tridentate fashion with the glucosamine function remaining pendant, and the Tc-99m complex was found to exhibit exceptional stability towards in vitro ligand exchange experiments.

URL<Go to ISI>://000226844900003