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Glucose-lowering properties of vanadium compounds: Comparison of coordination complexes with maltol or kojic acid as ligands

TitleGlucose-lowering properties of vanadium compounds: Comparison of coordination complexes with maltol or kojic acid as ligands
Publication TypeJournal Article
Year of Publication1997
AuthorsYuen, VG, Caravan, P, Gelmini, L, Glover, N, McNeill, JH, Setyawati, IA, Zhou, Y, Orvig, C
JournalJournal of Inorganic Biochemistry
Volume68
Pagination109-116
Date PublishedNov
Type of ArticleArticle
ISBN Number0162-0134
KeywordsALUMINUM(III), BIOINORGANIC CHEMISTRY, BIS(MALTOLATO)OXOVANADIUM(IV) BMOV, DIABETIC RATS, INHIBITOR, INSULIN MIMETIC AGENT, ISOLATED RAT ADIPOCYTES, LABILE, METABOLISM, OXOVANADATES, VANADATE
Abstract

Bis(kojato)oxovanadium(IV) [abbreviated VO(ka)(2)], a close chemical analog of the insulin-mimetic lead compound bis(maltolato) oxovanadium (IV) - abbreviated BMOV or VO(ma)(2) - is reported and its reaction chemistry and insulin-mimetic properties are presented. VO(ka)(2) [log K-1 = 7.61(10), log K-2 = 6.89(6), log beta(2) = 14.50(16)] has a reaction chemistry which directly parallels that of VO(ma)(2). In aqueous solution it is more slowly oxidized by molecular oxygen to [VO2(ka)(2)](-) than is VO(ma)(2) to [VO2(ma)(2)](-). Variable pH electrochemistry and variable pH V-51 NMR of solutions of VO(Ka)(2) are presented and contrasted with the corresponding results for VO(ma)(2). Time course studies (24 hr) in Sn-diabetic rats following the oral or ip administration of VO(ka)(2), VO(ma)(2), VO2+ (vanadyl) as vanadyl sulfate (VOSO4), and [VO2(ma)(2)](-) as its [NH4](+) salt have been performed, as have chronic oral studies comparing VO(ka)(2) and VO(ma)(2) over a six week period. lit all studies, the most potent form of vanadium was the neutrally charged water soluble, complex VO(ma)(2). (C) 1997 Elsevier Science Inc.

URL<Go to ISI>://A1997YA96300005