Title | Heck reaction of amino acid derived vinyl substrates in the synthesis of homotyrosinol derivatives. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Liang, H, Zhou, Y, Ciufolini, MA |
Journal | Synthesis |
Pagination | 2515 - 2520 |
Date Published | 2010/// |
ISBN Number | 0039-7881 |
Keywords | amino acid vinylglycinol Heck coupling iodophenyl acetate palladium phenylurea, homotyrosinol deriv prepn |
Abstract | An avenue to homotyrosinol derivs. through a Heck coupling of 4-iodophenyl acetate with a vinylglycinol deriv. required extensive screening of catalysts and conditions. The use of Pd(OAc)2 and N-phenylurea as the ligand ultimately provided excellent results. [on SciFinder(R)] |