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Improved procedure for the bimolecular oxidative amidation of phenols

TitleImproved procedure for the bimolecular oxidative amidation of phenols
Publication TypeJournal Article
Year of Publication2008
AuthorsLiang, H, Ciufolini, MA
JournalJournal of Organic Chemistry
Volume73
Pagination4299-4301
Date PublishedJun
Type of ArticleArticle
ISBN Number0022-3263
KeywordsDERIVATIVES, ETHERS, FR901483, HYPERVALENT IODINE OXIDATION, lactones, REAGENTS, SPIROLEUCETTADINE
Abstract

Trifluoroacetic acid (TFA) is an effective promoter of the bimolecular Ritter-like oxidative amidation of 4-substituted phenols induced by PhI(OAc)(2) in MeCN. This suppresses the need for fluoroalcohol cosolvents, increases the yields, and facilitates isolation/purification procedures.
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