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An Improved Synthesis of Pyridine-Thiazole Cores of Thiopeptide Antibiotics

TitleAn Improved Synthesis of Pyridine-Thiazole Cores of Thiopeptide Antibiotics
Publication TypeJournal Article
Year of Publication2009
AuthorsAulakh, VS, Ciufolini, MA
JournalJournal of Organic Chemistry
Volume74
Pagination5750-5753
Date PublishedAug
Type of ArticleArticle
ISBN Number0022-3263
Keywords1ST, AMYTHIAMICIN-D, CONSTRUCTION, GE2270-A, KEY BUILDING-BLOCKS, macrocycle, MICROCOCCIN P1, ONE-POT, PROMOTHIOCIN, SYNTHESIS, THIOSTREPTON
Abstract

The oxidation of 2-methylthiazoles to 2-formylthiazoles simplifies the implementation of the Bagley variant of the Bohlmann-Rahtz reaction as a key step in a concise new route to pyridine cores of thiopeptide antibiotics.
URL<Go to ISI>://000268480300104