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Intestinal absorption of trace amounts of aluminium in rats studied with (26)aluminium and accelerator mass spectrometry

TitleIntestinal absorption of trace amounts of aluminium in rats studied with (26)aluminium and accelerator mass spectrometry
Publication TypeJournal Article
Year of Publication1997
AuthorsSchonholzer, KW, Sutton, RAL, Walker, VR, Sossi, V, Schulzer, M, Orvig, C, Venczel, E, Johnson, RR, Vetterli, D, DittrichHannen, B, Kubik, P, Suter, M
JournalClinical Science
Volume92
Pagination379-383
Date PublishedApr
Type of ArticleArticle
ISBN Number0143-5221
KeywordsAL-26, aluminium, aluminium citrate, aluminium hydroxide, aluminium maltolate, DIALYSIS ENCEPHALOPATHY, GASTROINTESTINAL ABSORPTION, OSTEODYSTROPHY, sodium citrate
Abstract

1. Until recently studies of intestinal aluminium absorption used pharmacological amounts of stable Al-27. 2. To examine the intestinal absorption of trace amounts of different chemical compounds of aluminium, in the present study we have employed the long half-life isotope of aluminium, Al-26, and accelerator mass spectrometry, Trace amounts of Al-26 (2.7-12.1ng) as the hydroxide, citrate, citrate plus 1 mmol/kg sodium citrate, or maltolate respectively, were administered to four groups of rats (n = 9 per group) by gavage, Blood and urine samples were collected for 5h and the Al-26 content (as a percentage of the administered dose) determined by accelerator mass spectrometry, 3. The 5h urinary Al-26 excretion amounted to 0.1+/-0.02, 0.7+/-0.2, 5.1+/-1.5 and O.1+/-0.1% of administered dose in the four groups respectively, There was a strong positive correlation between peak plasma Al-26 (r = 0.98) and urinary Al-26 excretion in individual animals (P<0.001), 4. We conclude that the fractional intestinal absorption of trace oral doses of aluminium hydroxide is at least 0.1% (compared with the previous estimate of 0.01% using large Al-27 Oral loads), Absorption of aluminium citrate given alone is significantly greater (0.7%) and is further increased to 5% by the accompanying sodium citrate, consistent with an enhancing effect of added citrate upon mucosal aluminium permeability. Aluminium maltolate absorption approximates that of aluminium hydroxide (0.1%).

URL<Go to ISI>://A1997WT73200009