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Lanthanide containing compounds for therapeutic care in bone resorption disorders

TitleLanthanide containing compounds for therapeutic care in bone resorption disorders
Publication TypeJournal Article
Year of Publication2007
AuthorsBarta, CA, Sachs-Barrable, K, Jia, J, Thompson, KH, Wasan, KM, Orvig, C
JournalDalton Transactions
Pagination5019-5030
ISBN Number1477-9226
Abstract

{Lanthanide ions, Ln( III), are known functional mimics of Ca( II) ions and have been shown to affect the bone remodeling cycle. Exploiting this disruption to the bone remodeling cycle has potential for the treatment of bone density disorders, such as osteoporosis. In an effort to find new orally active agents for these disorders, a series of Ln( III) containing complexes incorporating small, non-toxic, bidentate pyrone and pyridinone ligands have been synthesized and characterized ( LnL(3)

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