Research & Teaching Faculty

Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia

TitleMetabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia
Publication TypeJournal Article
Year of Publication2009
AuthorsBeasley, CL, Dwork, AJ, Rosoklija, G, Mann, JJ, Mancevski, B, Jakovski, Z, Davceva, N, Tait, AR, Straus, SK, Honer, WG
JournalSchizophrenia Research
Volume109
Pagination159-166
Date PublishedApr
Type of ArticleArticle
ISBN Number0920-9964
KeywordsANTERIOR CINGULATE CORTEX, Axon, BASAL GANGLIA, composition, CORPUS-CALLOSUM, EXPRESSION, fiber, HUMAN INTERNAL CAPSULE, Internal capsule, LACTATE, MENTAL-ILLNESS, METABOLITE, myelin, POLARIZED-LIGHT, POSTMORTEM BRAINS, PREFRONTAL CORTEX, SEVERE
Abstract

{The anterior limb of the internal capsule (ALIC) is the major white matter tract providing reciprocal connections between the frontal cortex, striatum and thalamus. Mounting evidence suggests that this tract may be affected in schizophrenia, with brain imaging studies reporting reductions in white matter volume and density, changes in fractional anisotropy and reduced asymmetry. However, the molecular correlates of these deficits are currently unknown. The aim of this study was to identify alterations in protein and metabolite levels in the ALIC in schizophrenia. Samples were obtained post-mortem from individuals with schizophrenia (n = 15) and non-psychiatric controls (n = 13). Immunoreactivity for the myelin-associated protein myelin basic protein (MBP), and the axonal-associated proteins phosphorylated neurofilament and SNAP-25 was measured by enzyme-linked immunoadsorbent assay (ELISA). Metabolite concentrations were quantified by proton nuclear magnetic resonance (H-1 NMR) spectroscopy. Levels of myelin- or axonal-associated proteins did not differ between groups. Overall differences in metabolite concentrations were observed between the two groups (MANOVA F=2.685

URL<Go to ISI>://000265516300023