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Metal complexes of maltol and close analogues in medicinal inorganic chemistry

TitleMetal complexes of maltol and close analogues in medicinal inorganic chemistry
Publication TypeJournal Article
Year of Publication2006
AuthorsThompson, KH, Barta, CA, Orvig, C
JournalChemical Society Reviews
Volume35
Pagination545-556
Type of ArticleReview
ISBN Number0306-0012
KeywordsDIELS-ALDER REACTION, ENHANCED PFE(3+) VALUES, ETHYL MALTOL, evaluation, IN-VIVO, ION SEQUESTERING AGENTS, IRON-DEFICIENCY ANEMIA, MONOLAYERS, MRI CONTRAST AGENTS, ORAL, RAT SMALL-INTESTINE, SELF-ASSEMBLED, VANADYL SULFATE
Abstract

The family of hydroxypyrones and close congeners, the hydroxypyridinones, is a particularly versatile class of ligands. The most widely investigated for medicinal applications are the 3-hydroxy-4-pyrones and the 1,2- 3,2- and 3,4-hydroxypyridinones. Key features of these ligands are: a six-membered ring, with a ring N or O atom either ortho or para to a ketone group, and two ortho exocyclic oxygen atoms. Readily functionalizable, the hydroxypyrones and hydroxypyridinones allow one to achieve a range of di- and trivalent metallocomplex stabilities and can include tissue or molecular targeting features by design. Research over the past several decades has greatly expanded the array of ligands that are the subject of this critical review. Ligand applications as diverse as iron removal or supplementation, contrast agents in imaging applications, and mobilization of undesirable excess metal ions will be surveyed herein.

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