| Title | [nat/89Zr][Zr(pypa)]: Thermodynamically Stable and Kinetically Inert Binary Nonadentate Complex for Radiopharmaceutical Applications |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Southcott, L, LI, LILY, Patrick, BO, Stephan, H, Jaraquemada-Pelaez, Mde Guadalu, Orvig, C |
| Journal | Inorg. Chem. |
| Volume | 60 |
| Pagination | 18082-18093 |
| Date Published | 11/2021 |
| Abstract | { H4pypa is a nonadentate nonmacrocyclic chelator, which previously demonstrated high affinity for scandium-44, lutetium-177, and indium-111. Herein, we report the highly stable binary [Zr(pypa)] complex; the nonradioactive complex was synthesized and characterized in detail using high-resolution electrospray-ionization mass spectroscopy (HR-ESI-MS) and various nuclear magnetic resonance spectroscopies (NMR), which revealed C2v symmetry of the complex. The geometry of [Zr(pypa)] was further detailed via X-ray crystallography and compared with the structure of [Fe(Hpypa)]. Despite a slow complexation rate with an association half-life of 31.4 h at pH 2 and room temperature, the [Zr(pypa)] complex is thermodynamically stable (log KML = 38.92 |
| URL | https://doi.org/10.1021/acs.inorgchem.1c02709 |
| DOI | 10.1021/acs.inorgchem.1c02709 |
| Refereed Designation | Refereed |
