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Neopetrosiamides, peptides from the marine sponge Neopetrosia sp that inhibit amoeboid invasion by human tumor cells

TitleNeopetrosiamides, peptides from the marine sponge Neopetrosia sp that inhibit amoeboid invasion by human tumor cells
Publication TypeJournal Article
Year of Publication2005
AuthorsWilliams, DE, Austin, P, Diaz-Marrero, AR, Van Soest, R, Matainaho, T, Roskelley, CD, Roberge, M, Andersen, RJ
JournalOrganic Letters
Volume7
Pagination4173-4176
Date PublishedSep
Type of ArticleArticle
ISBN Number1523-7060
KeywordsANTI-INVASION, MIGRATION, PAPUA-NEW-GUINEA, PROLINE, PROTEOLYSIS, STRONGYLOPHORINE-26
Abstract

Neopetrosiamdes A (1) and B (2), two diastereomeric tricyclic peptides that inhibit amoeboid invasion of human tumor cells, have been isolated from the marine sponge Neopetrosia sp. collected in Papua New Guinea. The structures of the neopetrosiamides were elucidated by analysis of MS and NMR data and confirmed by chemical degradation.
URL<Go to ISI>://000231858100028