| Title | Nickel-Catalyzed Csp(2)-Csp(3) Bond Formation by Carbon-Fluorine Activation |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Sun, AD, Leung, K, Restivo, AD, LaBerge, NA, Takasaki, H, Love, JA |
| Journal | CHEMISTRY-A EUROPEAN JOURNAL |
| Volume | 20 |
| Pagination | 3162-3168 |
| Date Published | MAR 10 |
| ISSN | 0947-6539 |
| Abstract | We report herein a general catalytic method for Csp(2)Csp(3) bond formation through CF activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with -hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks. |
| DOI | 10.1002/chem.201303809 |
