Title | Synthetic and biosynthetic routes to nitrogen–nitrogen bonds |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | He, H-Y, Niikura, H, Du, Y-L, Ryan, KS |
Journal | Chem. Soc. Rev. |
Volume | 51 |
Pagination | 2991-3046 |
Abstract | The nitrogen–nitrogen bond is a core feature of diverse functional groups like hydrazines{,} nitrosamines{,} diazos{,} and pyrazoles. Such functional groups are found in >300 known natural products. Such N–N bond-containing functional groups are also found in significant percentage of clinical drugs. Therefore{,} there is wide interest in synthetic and enzymatic methods to form nitrogen–nitrogen bonds. In this review{,} we summarize synthetic and biosynthetic approaches to diverse nitrogen–nitrogen-bond-containing functional groups{,} with a focus on biosynthetic pathways and enzymes. |
URL | http://dx.doi.org/10.1039/C7CS00458C |
DOI | 10.1039/C7CS00458C |
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