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  3. Spirastrellolide A: Revised structure, progress toward the relative configuration, and inhibition of protein phosphatase 2A

Spirastrellolide A: Revised structure, progress toward the relative configuration, and inhibition of protein phosphatase 2A

TitleSpirastrellolide A: Revised structure, progress toward the relative configuration, and inhibition of protein phosphatase 2A
Publication TypeJournal Article
Year of Publication2004
AuthorsWilliams, DE, Lapawa, M, Feng, XD, Tarling, T, Roberge, M, Andersen, RJ
JournalOrganic Letters
Volume6
Pagination2607-2610
Date PublishedJul
Type of ArticleArticle
ISBN Number1523-7060
Abstract

The structure of spirastrellolide A, a novel macrolide isolated from the marine sponge Spirastrella coccinea, has been revised to accommodate new MS and chemical transformation data. Relative configurations of three major fragments of the molecule have been elucidated from ROESY and coupling constant data. Spirastrellolide A has been shown to be a potent and fairly selective inhibitor of protein phosphatase 2A.
URL<Go to ISI>://000222706600030