| Title | A new [4]carceplex, and a crystal structure and dynamic combinatorial chemistry of a [5]carceplex |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Sun, JY, Patrick, BO, Sherman, JC |
| Journal | Tetrahedron |
| Volume | 65 |
| Pagination | 7296-7302 |
| Date Published | Aug |
| Type of Article | Article |
| ISBN Number | 0040-4020 |
| Keywords | carceplex, Disulfide, Dynamic combinatorial chemistry, Guest release, HEMICARCEPLEXES, MOLECULES, supramolecular, TEMPLATION |
| Abstract | A new [4]carceplex (2-guest) is reported. It is composed of two cavitands linked by four disulfide bonds. It forms twistomers, which interconvert on a millisecond timescale. The energy barrier for interconversion of twistomers is guest-dependent. Formation of [4]carceplex 2-guest is template dependent. The selectivity in templates is flat relative to most previous related template work. Larger kin [5]carceplex 1.guests were reinvestigated. A crystal structure confirms the twist between the hemispherical cavitands. Use of a redox buffer allowed dynamic combinatorial chemistry to be performed between pairs of templates. (C) 2009 Elsevier Ltd. All rights reserved. |
| URL | <Go to ISI>://000269098700012 |
