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Radiohalogens for imaging and therapy

TitleRadiohalogens for imaging and therapy
Publication TypeJournal Article
Year of Publication2005
AuthorsAdam, MJ, Wilbur, DS
JournalChemical Society Reviews
Volume34
Pagination153-163
Type of ArticleReview
ISBN Number0306-0012
KeywordsBRAIN, CANCER, F-18, LIGAND, MONOCLONAL-ANTIBODIES, PET, POSITRON-EMISSION-TOMOGRAPHY, RADIOIODINATION, RADIOTHERAPY, SPECT
Abstract

Radiohalogens play a very important role in radiopharmaceuticals used for medical imaging ( now referred to as molecular imaging) and therapy applications. Development of new radiopharmaceuticals that have radiohalogens incorporated requires an understanding of parameters that are unique to chemistry involving these radionuclides. Those parameters include requirement for production and purification of the halogen radionuclides, as well as development of reaction conditions for use with high specific activity short-lived radionuclides. In this tutorial review, several radiohalogens, their radiolabeling chemistry and their application to medical imaging and therapy are discussed.

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