Title | A Route to the Heterocyclic Cluster of the E-Series of Thiopeptide Antibiotics |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Hwang, H-J, Ciufolini, MA |
Journal | JOURNAL OF ORGANIC CHEMISTRY |
Volume | 80 |
Pagination | 4184-4188 |
Date Published | APR 17 |
ISSN | 0022-3263 |
Abstract | A concise route to the 3-hydroxypyridine core of thiopeptide antibiotics such as nocathiacin is described. Key phases of the sequence involve a modified Hantzsch pyridine construction and a chemoselective Peng deprotection of a phenolic MOM ether. |
DOI | 10.1021/acs.joc.5b00315 |