| Title | RUBROLIDES-A-H, METABOLITES OF THE COLONIAL TUNICATE RITTERELLA-RUBRA |
| Publication Type | Journal Article |
| Year of Publication | 1991 |
| Authors | Miao, SC, Andersen, RJ |
| Journal | Journal of Organic Chemistry |
| Volume | 56 |
| Pagination | 6275-6280 |
| Date Published | Oct |
| Type of Article | Article |
| ISBN Number | 0022-3263 |
| Keywords | C-13 ASSIGNMENTS, CARIBBEAN TUNICATE, ECTEINASCIDIA-TURBINATA, H-1, MARINE NATURAL-PRODUCTS, NMR, SIGILLINOIDES |
| Abstract | Rubrolides A (1) to H (8), a new family of biologically active tunicate metabolites, have been isolated from Ritterella rubra. The structures of the rubrolides were solved by a combination of spectroscopic analysis and chemical interconversions. Rubrolides B (2) and H (8) represent some of the first chlorinated metabolites known from tunicates. The rubrolides are potent in vitro antibiotics and they show moderate but selective inhibition of protein phosphatases 1 and 2A. |
| URL | <Go to ISI>://A1991GM57600012 |
