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Sintokamides A to E, Chlorinated Peptides from the Sponge Dysidea sp that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells

TitleSintokamides A to E, Chlorinated Peptides from the Sponge Dysidea sp that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells
Publication TypeJournal Article
Year of Publication2008
AuthorsSadar, MD, Williams, DE, Mawji, NR, Patrick, BO, Wikanta, T, Chasanah, E, Irianto, HE, Van Soest, R, Andersen, RJ
JournalOrganic Letters
Volume10
Pagination4947-4950
Date PublishedNov
Type of ArticleArticle
ISBN Number1523-7060
KeywordsAMINO-ACID, BARBAMIDE, biosynthesis, CYANOBACTERIUM, DOMAIN, HERBACEA, METABOLITES
Abstract

The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells.
URL<Go to ISI>://000260534500060