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Studies toward the synthesis of contignasterol: Functionalization of the steroidal A,B ring system

TitleStudies toward the synthesis of contignasterol: Functionalization of the steroidal A,B ring system
Publication TypeJournal Article
Year of Publication2002
AuthorsRogers, C, Shen, YP, Burgoyne, D, Piers, E
JournalSynthetic Communications
Volume32
Pagination2991-3002
Type of ArticleArticle
ISBN Number0039-7911
KeywordsEPOXIDATION, lithium, ring opening, stereoselective reduction, steroid
Abstract

The synthesis of androstane-3alpha,4beta,6alpha,7beta-tetrol-17-one (2), a potentially key intermediate for the preparation of contignasterol (1), was achieved by functionalization of the A,B-ring portion or the readily available androst-4-ene-3,17-dione (3).

URL<Go to ISI>://000178124600011