Title | Syntheses of p-nitrophenyl 3-and 4-thio-beta-D-glycopyranosides |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Chen, H-M, Withers, SG |
Journal | CARBOHYDRATE RESEARCH |
Volume | 345 |
Pagination | 2596-2604 |
Date Published | DEC 10 |
ISSN | 0008-6215 |
Abstract | Thioglycosides have proved to be useful enzymatically stable analogs of glycosides for structural and mechanistic studies and their synthesis is considerably simplified through the use of thioglycoligases As part of an investigation Into the use of thioglycosides as potential pharmacological chaperones and as components of glycoproteins and glycolipids the syntheses of p-nitrophenyl 3-thio-beta-D-galactopyranoside phenyl 1 4-dithio-beta-D-glucopyranoside p-nitrophenyl 4-thio-beta-D-mannopyranoside and p-nitrophenyl 2-acetamido-2-deoxy-4-thio-beta-D-mannopyranoside are described (C) 2010 Elsevier Ltd All rights reserved |
DOI | 10.1016/j.carres.2010.10.001 |