| Title | The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Rye, CS, Withers, SG |
| Journal | CARBOHYDRATE RESEARCH |
| Volume | 339 |
| Pagination | 699-703 |
| Date Published | FEB 25 |
| ISSN | 0008-6215 |
| Abstract | A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars. (C) 2004 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.carres.2003.12.011 |
