| Title | Trisphaerolide A, a novel polyketide from the Dominican sponge Erylus trisphaerus |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | van Altena, I, Van Soest, R, Roberge, M, Andersen, RJ |
| Journal | Journal of Natural Products |
| Volume | 66 |
| Pagination | 561-563 |
| Date Published | Apr |
| Type of Article | Article |
| ISBN Number | 0163-3864 |
| Keywords | biosynthesis, CELL-CYCLE, DNA-DAMAGE CHECKPOINT, INHIBITION, ISOGRANULATIMIDE |
| Abstract | The structure of trisphaerolide A (1), a mildly cytotoxic metabolite isolated from extracts of the marine sponge Erylus trisphaerus collected in Dominica, has been elucidated by detailed analysis of spectroscopic data. Trisphaerolide A (1) has a putative polyketide biogenesis, incorporating a rare variant on the standard pathway, which involves the addition of methyl branches arising from C-2 carbons of acetate units to chain carbons that arise from C-1 of acetate units. |
| URL | <Go to ISI>://000182562800025 |
