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Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes

TitleUnprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes
Publication TypeJournal Article
Year of Publication2001
AuthorsMikata, Y, Shinohara, Y, Yoneda, K, Nakamura, Y, Brudzinska, I, Tanase, T, Kitayama, T, Takagi, R, Okamoto, T, Kinoshita, I, Doe, M, Orvig, C, Yano, S
JournalBioorganic & Medicinal Chemistry Letters
Volume11
Pagination3045-3047
Date PublishedDec
Type of ArticleArticle
ISBN Number0960-894X
KeywordsCISPLATIN, DNA, DRUGS, MOLECULES
Abstract

Eight carbohydrate-pendant platinum(II) complexes have been synthesized from carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xylose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the carbohydrate moieties reduced the toxicity inherent with platinum(II) complexes. (C) 2001 Elsevier Science Ltd. All rights reserved.

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