Title | Zirconium Catalyzed Hydroaminoalkylation for the Synthesis of α-Arylated Amines and N-Heterocycles |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Koperniku, A, Schafer, LL |
Journal | Chemistry – A European Journal |
Volume | 27 |
Pagination | 6334-6339 |
Keywords | alpha-arylated amines, HETEROCYCLES, HYDROAMINOALKYLATION, ZIRCONIUM |
Abstract | Abstract The zirconium catalyzed hydroaminoalkylation of alkenes with N-aryl- and sterically demanding N-alkyl-α-arylated secondary amines by using commercially available Zr(NMe2)4 is reported. N-phenyl- and N-isopropylbenzylamine are used as amine substrates to establish the alkene substrate scope. Exclusively linear products are obtained in the presence of bulky vinylsilanes. Challenging α-heteroarylated amines and functionalized alkene substrates are compatible with this easy to use catalyst, affording a new disconnection strategy for the atom- and step-economic preparation of selectively substituted saturated α-arylated heterocycles. |
URL | https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.202100014 |
DOI | 10.1002/chem.202100014 |
