Abstract:
One-pot reactions, if conducted in a consecutive, sequential or domino fashion, promise a highly efficient and efficacious synthetic access to many functional molecules of interest. In particular, heterocyclic systems are interesting due to their vast spectrum of applications. Transition metal catalyzed multi-component sequences have recently gained a considerable interest since they enable transformations with high tolerance of functional groups. Over the years we have established Pd-catalyzed entries to ynones, diynones, diynes, enals, enones, and boronates, which are valuable intermediates for in situ transformation into complex molecules in a one-pot fashion. Likewise, sequentially Pd-catalyzed processes have opened new avenues to one-pot syntheses of numerous classes of heterocyclic frameworks. Most interestingly, in sequentially Pd-catalyzed processes the same catalyst source is operative a second time without further catalyst addition. This one-pot methodological concept is most elegantly applied to the syntheses of various classes of functional heterocycles, ranging from functional chromophores and electrophores to luminophore, and as a key step in very concise syntheses of marine alkaloids, kinase inhibitors and anti-infectiva. By virtue, concise accesses to substance libraries of interest in organic materials and life sciences are efficiently enabled.
Biography:
Thomas J. J. Müller studied chemistry (1984-1989) at the University of München (LMU) (diploma 1989; Ph.D. 1992). After a post-doctoral stay at Stanford University (1993/1994), he developed his independent research at Technical University Darmstadt and LMU (1994-1999; habilitation 2000). After a professorship at the University of Heidelberg (2002-2006) he is a chaired full professor at the University of Düsseldorf since 2006, and since 2019 the spokesman of the Research Training Group 2482 funded by the German Science Foundation (DFG). His research interests encompass synthetic and physical-organic chemistry of functional chromophores, and the design of novel one-pot reactions, documented in more than 300 publications.