Chemistry 305: Biophysical Chemistry

Course Level: 
Third Year
Academic Year: 

Diffusion and Transport Phenomena
• Diffusion in one, two, and three dimensions
            Random walk (Brownian motion)
            Fick's laws
            Stokes-Einstein equation and molecular shapes
• Electrophoresis
• Sedimentation
            Svedberg equation
            Equilibrium and velocity sedimentation 
• Mass spectrometry

Macromolecular Interactions
• Thermodynamics and kinetics of macromolecular binding
• Analytical methods
            Biochemical/genetic approaches
            Spectroscopy (absorbance, fluorescence, circular/linear dichroism)
            Isothermal titration calorimetry
            Surface plasmon resonance
• Structure and dynamics 
• Allostery and co-operativity
• Single molecule approaches