Course Level:
Third Year
Academic Year:
2020/2021
Prof. John Sherman
Office: A243
822-2305
Text: No formal text. Use any introductory organic text.
Handouts: Some notes will be posted on the web and/or handed out. These will be mostly definitions and other data. The majority of notes will be in-class.
Outline:
A. Amino acids and peptides (4 weeks)
- Amino acids: structure, acid/base properties, review of pKa and electronic effects
- Reactions of amino acids
- Peptides: structure determination, synthesis of
B. Carbohydrates (4 weeks)
- Monosaccharides-structure, conformations (review)
- Reactions of monosaccharides
- Protecting groups
- Glycoside couplings
- Oligosaccharide structures
C. Organophosphate esters (2 weeks)
- Acid/base properties, hydrolysis mechanisms, synthesis of
- DNA/RNA synthesis
D. Pyridoxal phosphate and thiamin (1-2 weeks)
- Structure, function
- Mechanisms of catalytic reactions
Breakdown:
| midterm 1 | 15% |
| midterm 2 | 20% |
| final | 100% |