1. Introduction
2. Theory and Application of Mass Spectrometry
i) Ionization Techniques:
a) Electron impact
b) Fast Atom Bombardment
c) Chemical Ionization
d) MALDI
e) Electrospray
ii) Mass Analyzers:
a) Magnet Sector
b) Quadrupole
c) Time of Flight
d) FTICR
iii) High Resolution MS
iv) Analysis of Mass Spectral Fragmentation Patterns
3. Nuclear Magnetic Resonance Spectroscopy
i) Theory of NMR of Spin 1/2 Nuclei
ii) Theory of Chemical Shifts
iii) Theory of Scalar Coupling
iv) Analysis of 1D NMR Spectra
v) Nuclear Overhauser Effect
vi) Introduction to analysis of 2D NMR Spectra
4. Infrared Spectroscopy
i) Theory of Infrared Spectroscopy
ii) Analysis of IR Spectra
5. Ultraviolet/Visible Spectroscopy
i) Theory of UV/Visible Spectroscopy
ii) Analysis of UV/Visible Spectra
6. Applications of Spectroscopic Techniques to Chemical and Biochemical Problems - for example:
i) Use in Investigating Biosynthesis and Enzyme Mechanisms
ii) Use in Investigating Reaction Mechanisms
iii) Use in Protein Structure Determination
Textbooks:
Required Textbook: "Introduction to Organic Spectroscopy" Harwood & Claridge. Oxford University Press
Required Workbook:
"Organic Structures from Spectra, Third Edition" Field, Sternhell and Kalman. John Wiley and Sons