| Title | Glycosidase mechanisms |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Rye, CS, Withers, SG |
| Journal | CURRENT OPINION IN CHEMICAL BIOLOGY |
| Volume | 4 |
| Pagination | 573-580 |
| Date Published | OCT |
| ISSN | 1367-5931 |
| Abstract | Insights into glycosidase mechanisms have come from X-ray crystallographic studies on complexes with substrate analogs and inhibitors, representing all the intermediate species along the reaction coordinate. Site-directed mutagenesis continues to play a significant role in understanding mechanisms, but is also proving important in generating glycosidases of modified mechanism or specificity. |
| DOI | 10.1016/S1367-5931(00)00135-6 |
