| Title | Improved separation scheme for 44Sc produced by irradiation of natCa targets with 12.8 MeV protons |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Kurakina, ES, Wharton, L, Hoehr, C, Orvig, C, Magomedbekov, EP, Filosofov, D, Radchenko, V |
| Journal | Nucl. Med. Biol. |
| Volume | 104-105 |
| Pagination | 22-27 |
| Date Published | 11/2021 |
| ISSN | 0969-8051 |
| Keywords | Cation exchange, DGA, Irradiation of natural Ca, Radiochemical separation, radiolabeling, Sc |
| Abstract | Introduction 44Sc is of great interest as a positron emission tomography (PET) radionuclide due to its suitable nuclear characteristics: Eβ+max = 1.47MeV, branching ratio 94.3% and convenient half-life of 3.97 h. Here, 44Sc was produced via the widely used reaction 44Ca (p,n)44Sc using natural calcium as a target. Methods The irradiation was performed at TRIUMF using the 13 MeV cyclotron. The separation consisted of a combination of DGA branched resin and Dowex 50Wx8 (200–400 mesh). The distribution coefficients of Sc3+ on Dowex 50Wx8 (NH4+ form, 200–400 mesh) with ammonium α-hydroxyisobutyrate (pH = 4.8) medium were determined in this study. Results and conclusion The tested scheme allows both a reliable separation of 44Sc from the target material as well as from the other competitive metals and a final fraction with high specific activity. The achieved radiochemical yield was 95 ± 3%. |
| URL | https://www.sciencedirect.com/science/article/pii/S0969805121005102 |
| DOI | 10.1016/j.nucmedbio.2021.11.002 |
| Refereed Designation | Refereed |
