Title | Incorporation of 8-histaminyldeoxyadenosine [8-(2-(4-imidazolyl)ethylamino)-2 ’-deoxyriboadenosine] into oligodeoxyribonucleotides by solid phase phosphoramidite coupling |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Lermer, L, Hobbs, J, Perrin, DM |
Journal | Nucleosides Nucleotides & Nucleic Acids |
Volume | 21 |
Pagination | 651-664 |
Type of Article | Article |
ISBN Number | 1525-7770 |
Keywords | BEARING IMIDAZOLE, CATALYTIC REPERTOIRE, CLEAVAGE, DERIVATIVES, DNA, IMIDAZOLYL FUNCTIONALITIES, NUCLEIC-ACIDS, OLIGONUCLEOTIDES, RIBONUCLEASES, RNA |
Abstract | The 3’ phosphoramidite of 8-histaminyl deoxyadenosine has been prepared and successfully incorporated into a short oligodeoxyribonucleotide. The synthetic methodology leading to this preparation is given and the implications for developing new DNAzymes as well as probing unusual nucleic acid structures are discussed. |
URL | <Go to ISI>://000179627900003 |