Course Level:
Second Year
Academic Year:
2024/2025
Instructor: Dr. Jason Hein,
Office Hours: 2:00 pm – 3:00 pm Thursday
Course Outline (Subject to Change):
- Intro and Admin
- Carbonyls (Aldehydes and Ketones) Review, Nucleophilic Addition Reactions
- Nucleophilic Addition Reactions (con't), Acetals/Ketals
- Addition of Nitrogen Nucleophiles (Imines, Oximes, Hydrazones)
- Wittig Reaction and HWE
- Enol Chemistry
- Select Oxidations and Reductions (Clemensen, Wolff-Kichner), catch up/review
- Carboxylic Acids (Intro, Properties, Preparation)
- Carboxylic Acid Synthesis and Reactivity
- Carboxylic Acid Derivatives and Relative Reactivity
- Nucleophilic Acyl Substitution (NAS) Intro
- Review/Problem Solving Session (MT1 Prep)
- NAS Reactions (with water, alcohol)
- NAS Reactions (with ammonia and amines)
- NAS Reactions (con't): Interconversion of Functional Derivatives
- Organometallics, Reduction
- Enolate Anions and Enamines
- Aldol Reactions
- Claisen/Dieckmann Condensations
- Enamines
- Conjugate Addition Reactions
- Conjugate Addition Reactions
- Review / Catch up
- Review/Problem Solving Session (MT2 Prep)
- Aromaticity Definitions and Examples
- Reactions
- Electrophilic Aromatic Substitution Reactions (Chlorination)
- EAS (con't) (Nitration and Sulfonation)
- EAS (con't) Friedel-Crafts Alkylation and Acylation
- EAS with Substituted Aromatics
- Nucleophilic Aromatic Substitution
- Review / Catch up
- Diels-Alder Reaction
- Diels-Alder Reaction (con't): Geometry
- Sigmatropic Shifts (Claisen and Cope Rearrangements)
- Review / Catch-up
- Review/Problem Solving Session (Exam Prep)