Title | Total synthesis of topopyrones B and D |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Tan, JS, Ciufolini, MA |
Journal | Organic Letters |
Volume | 8 |
Pagination | 4771-4774 |
Date Published | Oct |
Type of Article | Article |
ISBN Number | 1523-7060 |
Keywords | DIRECTED ORTHO METALATION, HYPOXYXYLERONE, TOPOISOMERASE-I INHIBITORS |
Abstract | We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work. |
URL | <Go to ISI>://000241030900026 |
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